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Genetics analysis of haptoglobin gene in Fujian Han nationality

ZOU Qilian, LIN Ying, LIN Xiangquan, CHEN Yuanzhong

Frontiers of Medicine 2008, Volume 2, Issue 1,   Pages 105-107 doi: 10.1007/s11684-008-0019-9

Abstract: The frequency of in the population of Fujian Han nationality accounted for 0.340, among which childrenThe Hp phenotype frequency was 0.026 in which the four age groups accounted for 0.032, 0.046, 0.014 andThe frequency of gene is rising with increasing age.The frequency of Hp phenotype is highest in the middle aged group and then tends to drop with increasing

Keywords： different     haptoglobin     phenotype frequency     electrophoresis     middle    

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A novel variant in the gene in a large Chinese family with a unique phenotype of Clouston syndrome

Frontiers of Medicine 2023, Volume 17, Issue 2,   Pages 330-338 doi: 10.1007/s11684-022-0933-2

Abstract: confirm the diagnosis of this pedigree at the molecular level and summarize and analyse the clinical phenotypeWe identified a new clinical phenotype involving all nail needling pain in all patients and found a special

Keywords： Clouston syndrome     whole exome sequencing     GJB6 gene     novel variant     unique phenotype    

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Heterogeneity of chronic obstructive pulmonary disease: from phenotype to genotype

Xu Chen, Xiaomao Xu, Fei Xiao

Frontiers of Medicine 2013, Volume 7, Issue 4,   Pages 425-432 doi: 10.1007/s11684-013-0295-x

Abstract:

Chronic obstructive pulmonary disease (COPD) is one of the leading causes of morbidity and mortality throughout the world and is mainly characterized by persistent airflow limitation. Given that multiple systems other than the lung can be impaired in COPD patients, the traditional FEV1/FVC ratio shows many limitations in COPD diagnosis and assessment. Certain heterogeneities are found in terms of clinical manifestations, physiology, imaging findings, and inflammatory reactions in COPD patients; thus, phenotyping can provide effective information for the prognosis and treatment. However, phenotypes are often based on symptoms or pathophysiological impairments in late-stage COPD, and the role of phenotypes in COPD prevention and early diagnosis remains unclear. This shortcoming may be overcome by the potential genotypes defined by the heterogeneities in certain genes. This review briefly describes the heterogeneity of COPD, with focus on recent advances in the correlations between genotypes and phenotypes. The potential roles of these genotypes and phenotypes in the molecular mechanisms and management of COPD are also elucidated.

Keywords： chronic obstructive pulmonary disease     heterogeneity     phenotype     genotype     prediction    

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Effects of iron oxide nanoparticles on phenotype and metabolite changes in hemp clones ( L.)

Frontiers of Environmental Science & Engineering 2022, Volume 16, Issue 10, doi: 10.1007/s11783-022-1569-9

Abstract:

● Fe3O4 NPs increased the biomass and chlorophyll content of hemp clones.

Keywords： Fe3O4 nanoparticle     Hemp     Growth enhancement     THC     Metabolite    

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Clinical phenotype network: the underlying mechanism for personalized diagnosis and treatment of traditional

Xuezhong Zhou,Yubing Li,Yonghong Peng,Jingqing Hu,Runshun Zhang,Liyun He,Yinghui Wang,Lijie Jiang,Shiyan Yan,Peng Li,Qi Xie,Baoyan Liu

Frontiers of Medicine 2014, Volume 8, Issue 3,   Pages 337-346 doi: 10.1007/s11684-014-0349-8

Abstract: To investigate the underlying mechanisms of TCM personalized medicine, we constructed a clinical phenotypenetwork (CPN), in which the clinical phenotype entities like symptoms and diagnoses are presented as

Keywords： personalized medicine     complex network     clinical phenotype network     traditional Chinese medicine    

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IRF4 and IRF8 expression are associated with clinical phenotype and clinico-hematological response to

Frontiers of Medicine 2022, Volume 16, Issue 3,   Pages 403-415 doi: 10.1007/s11684-021-0858-1

Abstract: Patients with decreased IRF4 expression were correlated with a more developed MPN phenotype in myelofibrosisOur data indicate that the expression of IRF4 and IRF8 was associated with the MPN phenotype, which may

Keywords： myeloproliferative neoplasms     IRF4     IRF8     hydroxyurea     essential thrombocythemia    

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Changes of phenotype and function of human CD4 CD25 T cells induced by transfection of Foxp3

WU Kui, BI Yutian, WANG Yaoli, WANG Changzheng

Frontiers of Medicine 2008, Volume 2, Issue 4,   Pages 366-369 doi: 10.1007/s11684-008-0070-6

Abstract: The aim of this paper is to explore the effects of transfection of Foxp3 gene on the phenotype and functionCD4CD25 T cells acquired a regulatory phenotype and function after it was transduced with the Foxp3 gene
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Natural killer cells in liver diseases

Meijuan Zheng, Haoyu Sun, Zhigang Tian

Frontiers of Medicine 2018, Volume 12, Issue 3,   Pages 269-279 doi: 10.1007/s11684-018-0621-4

Abstract:

The liver has been characterized as a frontline lymphoid organ with complex immunological features such as liver immunity and liver tolerance. Liver tolerance plays an important role in liver diseases including acute inflammation, chronic infection, autoimmune disease, and tumors. The liver contains a large proportion of natural killer (NK) cells, which exhibit heterogeneity in phenotypic and functional characteristics. NK cell activation, well known for its role in the immune surveillance against tumor and pathogen-infected cells, depends on the balance between numerous activating and inhibitory signals. In addition to the innate direct “killer” functions, NK cell activity contributes to regulate innate and adaptive immunity (helper or regulator). Under the setting of liver diseases, NK cells are of great importance for stimulating or inhibiting immune responses, leading to either immune activation or immune tolerance. Here, we focus on the relationship between NK cell biology, such as their phenotypic features and functional diversity, and liver diseases.

Keywords： natural killer cell     phenotype     immune activation     immune tolerance     liver diseases    

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A frequency error estimation for isogeometric analysis of Kirchhoff–Love cylindrical shells

Frontiers of Structural and Civil Engineering doi: 10.1007/s11709-023-0006-x

Abstract: A frequency error estimation is presented for the isogeometric free vibration analysis of Kirchhoff–LoveBy analyzing the discrete isogeometric equations with the aid of harmonic wave assumption, the frequencyIn particular, the governing relationship of the continuum frequency for Kirchhoff–Love cylindrical shellsis naturally embedded into the frequency error measures without the need of explicit frequency expressionsNumerical results not only thoroughly verify the theoretical convergence rates of frequency solutions

Keywords： isogeometric analysis     Kirchhoff–Love cylindrical shell     free vibration     frequency error     convergence    

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Calculation of collision frequency function for aerosol particles in free molecule regime in presence

Xiaowei LUO, Yannick BENICHOU, Suyuan YU

Frontiers in Energy 2013, Volume 7, Issue 4,   Pages 506-510 doi: 10.1007/s11708-013-0275-5

Abstract: The collision frequency function for aerosol particles has already been calculated for the free moleculeforce, electric force and molecular forces, created by particles themselves, recalculated the collision frequencyAttractive forces increase naturally the collision frequency, while repulsive forces decrease it.

Keywords： aerosol particles     collision frequency function     coagulation    

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Fuel variability effect on flickering frequency of diffusion flames

Jizhao LI, Yang ZHANG

Frontiers in Energy 2009, Volume 3, Issue 2,   Pages 134-140 doi: 10.1007/s11708-009-0034-9

Abstract: The intent of this study is to investigate the fuel variability on the flickering frequency of diffusionIt was found that the low frequency oscillation of flow and flame structures depended only weakly onWhen a mixture of methane/propane at a ratio of 1:1 was used the peak flickering frequency was aroundMechanisms thought to produce changes in the dynamic response and frequency harmonics were discussed.

Keywords： fuel variability     flickering frequency     diffusion flames     dynamics of combustion    

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Capacity limitation of nuclear units in grid based on analysis of frequency regulation

Yiping DAI, Pan JIANG, Lin GAO, Weimin KAN, Xiaoqing XIAO, Ge JIN

Frontiers in Energy 2012, Volume 6, Issue 2,   Pages 148-154 doi: 10.1007/s11708-012-0174-1

Abstract: Based on the analysis of frequency regulation, mathematic models for nuclear units in the grid are establishedThe relationship between different styles of frequency regulation and the allowable capacity of the nuclear

Keywords： nuclear units capacity     overspeed     primary frequency control (PFC)     second frequency control (SFC)    

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Oscillation frequency of simplified arterial tubes

Hui AN, Fan HE, Lingxia XING, Xiaoyang LI

Frontiers of Mechanical Engineering 2009, Volume 4, Issue 3,   Pages 300-304 doi: 10.1007/s11465-009-0038-5

Abstract: To construct the spatial kinetic equation of an arterial tube and obtain its radial natural frequencyThe results show that the first-order frequency is 15.8 Hz and the obtained exact analytical solutions

Keywords： spatial kinematics     natural frequency     finite element method    

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Parameter identification of interconnected power system frequency after trip-out of high voltage transmission

Xuzhan ZHOU,Shanshan LIU,Mingkun WANG,Yiping DAI,Yaohua TANG

Frontiers in Energy 2014, Volume 8, Issue 3,   Pages 386-393 doi: 10.1007/s11708-014-0323-9

Abstract: Accurate modeling and parameters of high voltage (HV) grid are critical for stability research of system frequencyIn this paper, simulation modeling of the system frequency was conducted of an interconnected power system

Keywords： high voltage (HV) grid     frequency stability parameter identification     primary frequency regulation (PFR    

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Dependence of error sensitivity of frequency on bias voltage in force-balanced micro accelerometer

Lili CHEN, Wu ZHOU

Frontiers of Mechanical Engineering 2013, Volume 8, Issue 2,   Pages 146-149 doi: 10.1007/s11465-013-0260-z

Abstract:

To predict more precisely the frequency of force-balanced micro accelerometer with different biasvoltages, the effects of bias voltages on error sensitivity of frequency is studied.The resonance frequency of accelerometer under closed loop control is derived according to its operationsensitivity with designed parameters of structure, circuit and process error can be used to predict the frequency

Keywords： Micro-Electro-Mechanical Systems (MEMS)     micro accelerometer     force-balanced micro accelerometer     frequency    

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Title Author Date Type Operation

Genetics analysis of haptoglobin gene in Fujian Han nationality

ZOU Qilian, LIN Ying, LIN Xiangquan, CHEN Yuanzhong

Journal Article

A novel variant in the gene in a large Chinese family with a unique phenotype of Clouston syndrome

Journal Article

Heterogeneity of chronic obstructive pulmonary disease: from phenotype to genotype

Xu Chen, Xiaomao Xu, Fei Xiao

Journal Article

Effects of iron oxide nanoparticles on phenotype and metabolite changes in hemp clones ( L.)

Journal Article

Clinical phenotype network: the underlying mechanism for personalized diagnosis and treatment of traditional

Xuezhong Zhou,Yubing Li,Yonghong Peng,Jingqing Hu,Runshun Zhang,Liyun He,Yinghui Wang,Lijie Jiang,Shiyan Yan,Peng Li,Qi Xie,Baoyan Liu

Journal Article

IRF4 and IRF8 expression are associated with clinical phenotype and clinico-hematological response to

Journal Article

Changes of phenotype and function of human CD4 CD25 T cells induced by transfection of Foxp3

WU Kui, BI Yutian, WANG Yaoli, WANG Changzheng

Journal Article

Natural killer cells in liver diseases

Meijuan Zheng, Haoyu Sun, Zhigang Tian

Journal Article

A frequency error estimation for isogeometric analysis of Kirchhoff–Love cylindrical shells

Journal Article

Calculation of collision frequency function for aerosol particles in free molecule regime in presence

Xiaowei LUO, Yannick BENICHOU, Suyuan YU

Journal Article

Fuel variability effect on flickering frequency of diffusion flames

Jizhao LI, Yang ZHANG

Journal Article

Capacity limitation of nuclear units in grid based on analysis of frequency regulation

Yiping DAI, Pan JIANG, Lin GAO, Weimin KAN, Xiaoqing XIAO, Ge JIN

Journal Article

Oscillation frequency of simplified arterial tubes

Hui AN, Fan HE, Lingxia XING, Xiaoyang LI

Journal Article

Parameter identification of interconnected power system frequency after trip-out of high voltage transmission

Xuzhan ZHOU,Shanshan LIU,Mingkun WANG,Yiping DAI,Yaohua TANG

Journal Article

Dependence of error sensitivity of frequency on bias voltage in force-balanced micro accelerometer

Lili CHEN, Wu ZHOU

Journal Article